Generic Peptides PNC-27 5 mg Anticancer Research Peptide Vial

It is PNC-27, a synthetic chimeric peptide of 32 residues supplied as a 5 mg lyophilised research vial. The molecule joins the p53 domain 12-26, which binds HDM-2, to a membrane-penetrating sequence. The compound has no approved form anywhere, and all published work is preclinical, so it is a laboratory reagent rather than a medicine.

It binds HDM-2 on the surface of cancer cells, and the complex forms pores in the cell membrane, which lyses those cells while leaving normal cells intact in the same cultures. Selectivity in culture depends on HDM-2 appearing at the membrane. The related peptide PNC-28 uses a different penetrating sequence and behaves similarly in the same assays, which supports the mechanism rather than any clinical claim.

No half-life is established. There are no human pharmacokinetic data and no phase I to III trials, and the project fact base records no estimates from primary sources either. Any timing used in laboratory work therefore comes from the design of the experiment rather than from a measured profile, and it should be treated as unknown.

With 1 ml of bacteriostatic water the 5 mg vial gives 5 mg per ml, so 1 mg measures 0.2 ml on a U-100 syringe and 500 mcg measures 0.1 ml. Two millilitres give 2.5 mg per ml, which suits smaller drawn volumes. Add the solvent down the vial wall, do not shake, and store the solution at 2-8 C without freezing.

Nothing at human level, because the peptide has never been tested in controlled human studies. Cell culture work describes selective lysis of cancer cells, and no clinical safety data exist to quote. That absence is the important fact: there is no established human safety profile, no known interactions and no long-term information.

It is documented on its own, since its pore-forming HDM-2 route has nothing in common with the repair peptides on the same line, such as BPC 157 and TB 500. Blending unrelated peptides shortens the usable window of each, so separate vials are the practical approach in any laboratory setting.

Yes. The 5 mg vial is listed on this page with international and U.S. domestic shipping options, and the price charged matches the option you select. Orders are dispatched after payment confirmation. The product is sold strictly for laboratory research and is not a licensed medicine anywhere, so it may not be presented as a treatment.