Generic Peptides AICAR 50 mg and 100 mg Research Grade Vials

AICAR is the short name of acadesine, also written AICA-riboside, a small molecule that activates AMP-activated protein kinase. Its formula is C9H14N4O5, its mass is about 258 g/mol, its CAS number is 2627-69-2 and its ATC code is C01EB13. It was studied as a cardioprotective agent and in acute lymphoblastic leukaemia, and the human cardiac programme was stopped at the end of 2010.

No. AICAR is a nucleoside analog, which means it is built from a sugar and a heterocyclic base rather than from a chain of amino acids. It is sold in the same catalogue as research peptides because of the metabolic work it is used in, and its page sits in this line, but the compound itself has no peptide bond. That difference matters when a laboratory protocol is planned.

The compound enters the cell and is converted into ZMP, a nucleotide that mimics the effect of AMP on AMP-activated protein kinase and switches the enzyme on without any change in cellular energy charge. Downstream, skeletal muscle models show increased glucose uptake and p38 MAPK activity, and rodent studies report better endurance that seems to follow a shift of fast fibres towards an oxidative type.

Sterile or bacteriostatic water is added down the wall of the vial and the contents are swirled, not shaken; the solvent is not in the pack. Concentration is the amount on the label divided by the millilitres added, so 50 mg in 5 mL gives 10 mg per mL. The lyophilized vial is kept at 2-8 C, protected from light, and the mixed solution at 2-8 C for about four weeks.

No validated human safety profile exists for AICAR, because the cardiac programme was halted and no approved product followed. Reported items in the clinical literature include effects on glucose metabolism, which are expected of an AMPK activator, and bradycardia with haemodynamic changes in the cardiac setting. Injection site reactions are the common local effect in the injection class. Long term effects are not characterised, and the human dose is not established.

Yes. Activators of AMP-activated protein kinase are named in class S4, hormone and metabolic modulators, of the WADA Prohibited List, and acadesine has been on that list since 2009. Substances in that class are prohibited at all times, in and out of competition. In 2009 the BMJ reported traces of the compound in the blood of cyclists at the Tour de France, which is part of why the class was written.

Yes, both vial sizes are in stock on this page and can be ordered directly. The 50 mg and 100 mg vials ship internationally and there is no U.S. domestic option for this product. International shipping is about USD 35, orders are processed in one to two business days and transit runs four to ten days depending on the destination country.