Ursodeoxycholic Acid - Ursocol 150 mg, 300 mg and SR 450 mg

Ursodeoxycholic Acid - Ursocol 150 mg, 300 mg and SR 450 mg Tablets

Ursodeoxycholic acid, also called ursodiol, is a naturally occurring bile acid used as a medicine. It dissolves cholesterol gallstones in people who cannot have surgery, it prevents stones forming in people losing weight very quickly, and it is the standard treatment for primary biliary cholangitis (PBC), an autoimmune disease that slowly damages the small bile ducts in the liver. It is supplied here as Ursocol: 150 mg and 300 mg tablets and a 450 mg sustained-release tablet. Reflux that often comes with upper abdominal trouble is managed with a proton pump inhibitor such as Omeprazole.

• Three variants: Ursocol 150 mg, 300 mg and SR 450 mg
• 30 tablets per pack
• Dissolves cholesterol gallstones and treats primary biliary cholangitis
• A prescription medicine in most countries

Variant Comparison

All three variants contain the same active substance, so the difference is strength and release form.

The 150 mg and 300 mg tablets let the prescriber build the daily dose tablet by tablet, because dosing follows body weight. Ursocol SR 450 mg releases the medicine gradually, so it suits a stable dose that is easier to take across the day. Nausea that sometimes comes with gallbladder and liver problems is treated separately with Domperidone.

How Ursodeoxycholic Acid Works

Ursodeoxycholic acid changes the composition of bile. It reduces the cholesterol the liver puts into bile so that cholesterol dissolves instead of settling into stones, and it displaces more toxic bile acids that build up when bile flow is poor. In primary biliary cholangitis this lowers the toxic load on liver cells and slows damage to the small bile ducts. Digestion can fail for other reasons too: a shortage of pancreatic enzymes is corrected with Pancreatin, separately from bile flow.

Dosage & Administration

Dosing is based on body weight and the reason for treatment. In primary biliary cholangitis the usual adult dose is 13 to 15 mg per kg per day divided into two to four intakes, taken with food. For dissolving gallstones the dose is lower, 8 to 10 mg per kg per day split into two or three intakes. Tablets are swallowed with water, not chewed. Gallstones may need up to two years of continuous use. If you miss a dose, take it when you remember unless the next one is close; never double up. Do not stop without medical advice.

This product is a prescription medicine in most countries. Information provided is for educational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before use.