Pancreatin Creon Capsules - 10000, 25000 and 40000 Lipase Units

Pancreatin Creon Capsules - 10000, 25000 and 40000 Lipase Units

Pancreatin, also called pancrelipase, is a porcine pancreatic extract given when the pancreas stops making enough enzymes to digest food - exocrine pancreatic insufficiency. It is standard treatment in chronic pancreatitis, cystic fibrosis, pancreatic cancer and after pancreatic surgery. Typical signs are oily or pale floating stools, wind, bloating and weight loss; nausea may need an antiemetic such as Domperidone, which does not correct the enzyme shortage.

• Three strengths: Creon 10000, Creon 25000 and Creon 40000
• Porcine pancreatin with lipase, amylase and protease
• Taken with every meal, dose titrated to the diet
• Prescription-only, 90 capsules per pack

Variant Comparison

All three variants hold the same enteric-coated minimicrospheres and differ only in how much pancreatin each capsule contains.

Creon 10000 delivers 10,000 lipase, 8,000 amylase and 600 protease units; Creon 25000 delivers 25,000, 18,000 and 1,000; Creon 40000 delivers 40,000, 25,000 and 1,600. Meals are dosed by fat content rather than a fixed capsule count, so adults commonly start on Creon 25000 and change to Creon 40000 when a meal needs over 100,000 lipase units, which cuts the number of capsules swallowed.

How Pancreatin Works

The capsule dissolves in the stomach and frees hundreds of minimicrospheres with an acid-resistant coating that opens above pH 5.5 in the small intestine, releasing lipase, amylase and protease to split fats, starches and proteins for absorption. Because enzymes work only alongside food, timing matters as much as dose. Herbal liver products such as LIV.52 are sold for similar complaints but have no enzyme activity, and pale stools with yellow eyes or dark urine point away from insufficiency towards blocked bile flow, sometimes treated with Ursodeoxycholic Acid.

Dosage & Administration

Take one or two capsules during or immediately after each meal and snack with plenty of water, then increase slowly according to response. Capsules may be swallowed whole, or opened and the granules stirred into acidic soft food or juice such as apple sauce and swallowed at once without chewing; crushing or chewing damages the coating and irritates the mouth. If stools stay fatty, clinicians check the dose against the fat eaten and the acidity in the gut, and a proton pump inhibitor such as Pantoprazole or Omeprazole is sometimes added. Never exceed 10,000 lipase units per kg per day.

This product is a prescription medicine in most countries. Information provided is for educational purposes only and does not constitute medical advice. Consult a qualified healthcare professional before use.